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Article

FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis

6 May 2018

Abstract excerpt

While the transcription factor forkhead box M1 (FOXM1) is well known as a proto-oncogene, its potential role in lung fibroblast activation has never been explored. Here, we show that FOXM1 is more highly expressed in fibrotic than in normal lung fibroblasts in humans and mice. FOXM1 was required not only for cell proliferation in response to mitogens, but also for myofibroblast differentiation and apoptosis...

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PMID: 29733296
DOI: 10.1172/jci87631

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