Article

Mechanism of superior B cell immortalisation activity of type 1 Epstein-Barr virus

2015-01-01

Abstract excerpt

Epstein-Barr virus (EBV) establishes lifelong latent infections in humans. EBV isolates worldwide are classified as type 1 or type 2 based on their EBNA-2 gene sequence. Type 1 EBV is more efficient at B cell transformation, a property previously mapped to the EBNA-2 locus. Previous work using EREB2.5 cells in a trans-complementation assay showed that the superior ability of type 1 EBNA-2 to sustain B cell prolife...

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Literature Corpus work: de62b4d0-11af-585c-9ee0-df6cfb86cf64
DOI: 10.25560/23223

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