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Mechanism of superior B cell transformation by type 1 Epstein-Barr virus

2017-01-01

Abstract excerpt

The Epstein-Barr virus (EBV) is characterised by the ability to infect human B lymphocytes in vitro and to transform and immortalise them into lymphoblastoid cell lines (LCLs). EBV strains can be divided into type 1 and type 2, according to the sequence of the viral EBNA-2 protein. Type 1 strains exhibit a superior capacity to efficiently transform B cells and this was mapped to the type 1 EBNA-2 protein. Substitu...

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Literature Corpus work
b3f38aa2-cc27-5b6b-b65c-2b4387b7a2c3
DOI
10.25560/52427
Open publication

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