Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The latent membrane protein 2 gene of Epstein-Barr virus is important for efficient B cell immortalization.

The Journal of general virology - 1 Nov 1996

Brielmeier M, Mautner J, Laux G, Hammerschmidt W

Abstract excerpt

The viral latent membrane proteins 2 (LMP2) of Epstein-Barr virus (EBV) were analysed genetically to evaluate their role in B cell immortalization. LMP2 is transcribed as two differently spliced mRNAs which code for the LMP2A and -B proteins, also called terminal protein-1 and -2. LMP2A and -B are found in latently infected, growth-transformed B lymphocytes in vitro, in different human tumours, and in latently...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Cell Transformation, Viral
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Viral

Share to Herpesvirus 4, Human

Share to Mutation

Share to Tumor Cells, Cultured

Share to Viral Matrix Proteins

Source

Identifiers

PMID: 8922475
DOI: 10.1099/0022-1317-77-11-2807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The latent membrane protein 2 gene of Epstein-Barr virus is important for efficient B cell immortalization.PMID 8922475Read ↗

The last seven transmembrane and carboxy-terminal cytoplasmic domains of Epstein-Barr virus latent membrane protein 2 (LMP2) are dispensable for lymphocyte infection and growth transformation in vitro.Semantic proximity Read ↗

Immortalization of human primary B lymphocytes in vitro with DNA.Semantic proximity Read ↗

The only domain which distinguishes Epstein-Barr virus latent membrane protein 2A (LMP2A) from LMP2B is dispensable for lymphocyte infection and growth transformation in vitro; LMP2A is therefore nonessential.Semantic proximity Read ↗

LMP1 and EBNA2 constitute a minimal set of EBV genes for transformation of human B cellsSemantic proximity Read ↗

Latent membrane protein 1 is critical for efficient growth transformation of human B cells by epstein-barr virus.Semantic proximity Read ↗

Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survivalSemantic proximity Read ↗

The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfoldSemantic proximity Read ↗

Immortalization of human lymphocytes by Epstein-Barr virus.Semantic proximity Read ↗

Epstein-Barr virus nuclear protein 2 mutations define essential domains for transformation and transactivation.Semantic proximity Read ↗

The effects of the Epstein-Barr virus latent membrane protein 2A on B cell function.Semantic proximity Read ↗

The Effect of Epstein-Barr Virus Latent Membrane Protein 2 Expression on the Kinetics of Early B Cell InfectionSemantic proximity Read ↗

Epstein-Barr Virus LMP2A-Induced B-Cell Survival in Two Unique Classes of EμLMP2A Transgenic MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.