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Life on the Outside: The Rescue of Coxiella burnetii from Its Host Cell

27 Sept 2010

Abstract excerpt

For over seven decades, Coxiella burnetii, the causative agent of human Q fever, has been considered a prototypical obligate intracellular bacterium that relies exclusively on a eukaryotic cell for growth. Intracellularly, the organism prospers in an acidified, phagolysosome-like vacuole. C. burnetii has evolved to replicate in this harsh compartment by a mechanism involving acid activation of metabolism. The ?2...

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PMID: 21639786
DOI: 10.1146/annurev-micro-090110-102927

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