Article

Azetidines kill <i>Mycobacterium tuberculosis</i> without detectable resistance by blocking mycolate assembly

2020-09-03

Abstract excerpt

Tuberculosis (TB) is the leading cause of global morbidity and mortality resulting from infectious disease, with over 10 million new cases and 1.5 million deaths in 2019. This global emergency is exacerbated by the emergence of multi-drug-resistant MDR-TB and extensively-drug-resistant XDR-TB, therefore new drugs and new drug targets are urgently required. From a whole-cell phenotypic screen a series of azetidines...

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Literature Corpus work: de377b1c-2f7b-533f-a37f-313c44f0529f
DOI: 10.1101/2020.09.03.281170

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