Article

HBO1 Suppresses Anti-Tumor Immunity of CD8⁺ T Cells in Thyroid Cancer by Recruiting BRD4 to Regulate VTCN1 Expression

2026-03-25

Abstract excerpt

<title>Abstract</title> <p> Thyroid cancer is the most common endocrine malignancy. Although surgery remains the primary treatment, advanced disease frequently recurs or metastasizes, and subsequent therapies yield suboptimal outcomes. Immunotherapy holds promise, yet the underlying immune-evasion mechanisms remain incompletely understood. HBO1, a multifunctional acyltransferase, plays a significant role in tumo...

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Literature Corpus work: de34b7a5-b291-5c0c-917e-599ae36f6aba
DOI: 10.21203/rs.3.rs-9138728/v1

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