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Article

HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification.

Biology direct - 5 Mar 2025

Guo Enshuang, Li Lei, Yang Jiankun, Zhou Yongjian, Bai Lu, Zhu Weiwei, Hu Qiuyue, Wang Huifen, Liu Hongqiang

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma is a fatal malignancy that lacking specific therapies. Homeobox B4 (HOXB4) was negatively correlated with poor prognosis in cancers, but its role in hepatocellular carcinoma has not been elucidated. RESULTS: We confirmed that HOXB4 was downregulated in hepatocellular carcinoma tissues and lower HOXB4 expression associated with poor prognosis. Gain- and loss-of function...

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Topics

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Share to Adenosine
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Epithelial-Mesenchymal Transition

Share to Gene Expression Regulation, Neoplastic

Share to Homeodomain Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 40045399
DOI: 10.1186/s13062-025-00620-3
PMCID: PMC11884015

Genes

HOXB4
TKT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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