Back to search

Article

KIT ligand protects against both light-induced and genetic photoreceptor degeneration

2019-09-01

Abstract excerpt

Photoreceptor cell degeneration is a major cause of blindness and a considerable health burden during aging but effective therapeutic or preventive strategies have not so far become commercially available. Here we show in mouse models that signaling through the tyrosine kinase receptor KIT protects photoreceptor cells against both light-induced and inherited retinal degeneration. Upon light damage, photoreceptor c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
de27c342-6d10-5908-beb8-599ea60f3af4
DOI
10.1101/752030
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
KIT ligand protects against both light-induced and genetic photoreceptor degenerationDOI 10.1101/752030
MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stressSemantic proximity
High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3Semantic proximity
Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration.Semantic proximity
Autophagy disruption and mitochondrial stress precede photoreceptor necroptosis in multiple mouse models of inherited retinal disordersSemantic proximity
Autophagy disruption and mitochondrial stress precede photoreceptor necroptosis in multiple mouse models of inherited retinal disordersSemantic proximity
A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina.Semantic proximity
Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore VisionSemantic proximity
AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosaSemantic proximity
Preservation of Cone Photoreceptors after a Rapid yet Transient Degeneration and Remodeling in Cone-Only<i>Nrl</i><sup>−/−</sup>Mouse RetinaSemantic proximity
Lipocalin-2-mediated ferroptosis as a target for protection against light-induced photoreceptor degenerationSemantic proximity
Vitamin A treatment restores vision failures arising from Leber's hereditary optic neuropathy-linked mtDNA mutation.Semantic proximity
Long-term blue light exposure impairs mitochondrial dynamics in the retina in light-induced retinal degeneration in vivo and in vitroSemantic proximity
Select a neighboring publication to make it the new centre.