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Article

Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration.

Investigative ophthalmology & visual science - 29 Jul 2011

Lange Christina, Heynen Severin R, Tanimoto Naoyuki, Thiersch Markus, Le Yun-Zheng, Meneau Isabelle, Seeliger Mathias W, Samardzija Marijana, Caprara Christian, Grimm Christian

Abstract excerpt

PURPOSE: Hypoxic preconditioning activates hypoxia-inducible transcription factors (HIFs) in the retina and protects photoreceptors from light-induced retinal degeneration. The authors tested whether photoreceptor-specific activation of HIFs in normoxia is sufficient for protection. METHODS: Rod-specific Vhl knockdown mice were generated using the Cre-lox system with the rod opsin promoter controlling expression...

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Source

Identifiers

PMID: 21447692
DOI: 10.1167/iovs.11-7204

Genes

ERG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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