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Article

Lipocalin-2-mediated ferroptosis as a target for protection against light-induced photoreceptor degeneration

15 May 2025

Abstract excerpt

Abstract Background Retinal degeneration is a leading cause of blindness worldwide. The induction of ferroptosis has been identified as an important mechanism contributing to the loss of photoreceptors in retinal degeneration. Lipocalin-2 (LCN2) exhibits iron-regulatory properties and may modulate cell viability in various diseases. However, the effects of LCN2 on ferroptosis in retinal degeneration remain...

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PMID: 40375133
DOI: 10.1186/s10020-025-01250-1

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