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Nucleocapsid mutations R203K/G204R increase the infectivity, fitness, and virulence of SARS-CoV-2.

Cell host & microbe - 8 Dec 2021

Wu Haibo, Xing Na, Meng Kaiwen, Fu Beibei, Xue Weiwei, Dong Pan, Tang Wanyan, Xiao Yang, Liu Gexin, Luo Haitao, Zhu Wenzhuang, Lin Xiaoyuan, Meng Geng, Zhu Zhenglin

Abstract excerpt

Previous work found that the co-occurring mutations R203K/G204R on the SARS-CoV-2 nucleocapsid (N) protein are increasing in frequency among emerging variants of concern or interest. Through a combination of in silico analyses, this study demonstrates that R203K/G204R are adaptive, while large-scale phylogenetic analyses indicate that R203K/G204R associate with the emergence of the high-transmissibility...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34822776
DOI: 10.1016/j.chom.2021.11.005
PMCID: PMC8590493

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