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Article

Wilson Disease: Intersecting DNA Methylation and Histone Acetylation Regulation of Gene Expression in a Mouse Model of Hepatic Copper Accumulation.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2021

Sarode Gaurav V, Neier Kari, Shibata Noreene M, Shen Yuanjun, Goncharov Dmitry A, Goncharova Elena A, Mazi Tagreed A, Joshi Nikhil, Settles Matthew L, LaSalle Janine M, Medici Valentina

Abstract excerpt

BACKGROUND & AIMS: The pathogenesis of Wilson disease (WD) involves hepatic and brain copper accumulation resulting from pathogenic variants affecting the ATP7B gene and downstream epigenetic and metabolic mechanisms. Prior methylome investigations in human WD liver and blood and in the Jackson Laboratory (Bar Harbor, ME) C3He-Atp7btx-j/J (tx-j) WD mouse model revealed an epigenetic signature of WD, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34098115
DOI: 10.1016/j.jcmgh.2021.05.020
PMCID: PMC8487080

Genes

HDAC4
HDAC5
ATP7B

Provenance

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