Article
High-Calorie Diet Accelerates the Liver Tissue Degeneration and Induces Subcutaneous White-to-Brown Fat Conversion in Mice with a Single-Allele Atp7b Mutation.
The Journal of nutrition - 1 Dec 2025
Abbas Qussai, Petrova Elena S, Tsymbalenko Nadezhda V, Al Farroukh Mohammad, Magazenkova Daria N, Polishchuk Elena V, Petruzzelli Raffaella, Derkach Kira V, Kolos Elena A, Klyueva Natalia N, Skvortsov Alexey N, Di Sole Francesca, Shpakov Alexander O, Denisenko Alexandr D, Korzhevskii Dmitriy E, Gupta Arnab, Polishchuk Roman S, Puchkova Ludmila V, Ilyechova Ekaterina Yu
Abstract excerpt
BACKGROUND: Wilson disease (WD) is a hereditary autosomal-recessive disorder of copper metabolism caused by mutations in the ATP7B gene, which also leads to dysregulation of lipid metabolism. In Atp7b-/--mice, a high-calorie diet (HCD) aggravates WD symptoms. However, it remains unknown whether HCD induces similar effects in asymptomatic Atp7b+/--heterozygotes. OBJECTIVES: This study aimed to determine whether...
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