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Article

<i>Atp7b</i> −/− mice as a model for studies of Wilson's disease

19 Nov 2008

Abstract excerpt

Wilson's disease is a severe human disorder of copper homoeostasis. The disease is associated with various mutations in the ATP7B gene that encodes a copper-transporting ATPase, and a massive accumulation of copper in the liver and several other tissues. The most frequent disease manifestations include a wide spectrum of liver pathologies as well as neurological and psychiatric abnormalities. A combination of...

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PMID: 19021531
DOI: 10.1042/bst0361233

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