Article

Design, Expression, and Purification of a Soluble Form of the Retina-Specific Membrane Transporter, ABCA4

2025-05-23

Abstract excerpt

The ATP-binding cassette transporter A-subfamily member, ABCA4, is highly expressed in rod and cone photoreceptors in the retina, where it transports cis- and trans- retinal and is indispensable for vision. Genetic mutations in the ABCA4 gene lead to a wide range of inherited retinal degenerative diseases, including Stargardt disease (STGD1) and autosomal recessive cone-rod dystrophy. It is an integral membrane...

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Literature Corpus work: de1486cf-aaf0-5123-b2d3-932a314b6800
DOI: 10.1101/2025.05.22.655561

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