Article

Hypoxia-Mediated Molecular Interactions of Tissue-Specific Mesenchymal Stem Cells Drive Metabolic Reprogramming and Immunomodulation in Acute Graft-versus-Host Disease

2025-01-08

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Mesenchymal stem cells (MSCs) mediate immunomodulation through various mechanisms, including apoptosis, efferocytosis, and mitochondrial transfer. Our study investigates the impact of hypoxia preconditioning on the immune metabolic reprogramming and immunomodulatory potential of MSCs in acute graft-versus-host disease (aGVHD). Additionally, we explored the differential immun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d89167b1-8a19-56b3-8b43-f00ec0301eaf
DOI: 10.1101/2025.01.06.630457

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hypoxia-Mediated Molecular Interactions of Tissue-Specific Mesenchymal Stem Cells Drive Metabolic Reprogramming and Immunomodulation in Acute Graft-versus-Host DiseaseDOI 10.1101/2025.01.06.630457Read

Concurrent hypoxia and apoptosis imparts immune programming potential in mesenchymal stem cells: Lesson from acute graft-versus-host-disease modelSemantic proximity Read

Synergistic Hypoxia and Apoptosis Conditioning Unleashes Superior Mesenchymal Stem Cells Efficacy in Acute Graft-versus-Host-DiseaseSemantic proximity Read

Priming of MSCs with inflammation-relevant signals affects extracellular vesicle biogenesis, surface markers, and modulation of T cell subsetsSemantic proximity Read

Effects of Oxidative Stress on Mesenchymal Stem Cell BiologySemantic proximity Read

Mesenchymal Stem/Stromal Cells: A Review for Its Use After Allogeneic Hematopoietic Stem Cell TransplantationSemantic proximity Read

Mesenchymal stem cells—the master immunomodulatorsSemantic proximity Read

The immunomodulatory function of mesenchymal stem cells: mode of action and pathwaysSemantic proximity Read

Integrated transcriptomic, phenotypic, and functional study reveals tissue-specific immune properties of mesenchymal stromal cellsSemantic proximity Read

Mesenchymal Stromal Cells Affect Disease Outcomes via Macrophage PolarizationSemantic proximity Read

How to enhance MSCs therapeutic properties? An insight on potentiation methodsSemantic proximity Read

Revisiting the Mesenchymal “Stem vs. Stromal” Cell Dichotomy and Its Implications for Development of Improved Potency MetricsSemantic proximity Read

Mesenchymal Stromal Cell Therapy in Ischemia/Reperfusion Injury.Semantic proximity Read