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Article

MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling

6 Jan 2022

Abstract excerpt

There is a continued need to identify novel therapeutic targets to prevent the mortality associated with prostate cancer. In this context, mitochondrial Rho GTPase 2 (MIRO2) mRNA was upregulated in metastatic prostate cancer compared with localized tumors, and higher MIRO2 levels were correlated with poor patient survival. Using human cell lines that represent androgen-independent or -sensitive prostate cancer,...

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PMID: 34992146
DOI: 10.1158/1541-7786.mcr-21-0374

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