Article

Endogenous insulin mediates dynamic coordination between pancreatic cancer and systemic metabolism

2026-08-27

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is commonly associated with obesity, diabetes, and cachexia. The pancreatic anabolic hormone, insulin, is implicated in each of these metabolic diseases, but how insulin levels affect tumor growth and relevant host physiological factors, was unclear. To address this, we transplanted orthotopic PDAC patient-derived organoids into mice consuming a hyperinsulinemia-inducing hig...

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Literature Corpus work: ddc3a582-8038-5c53-9f7f-d990cf5c8a3a
DOI: 10.64898/2026.08.26.745597

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