Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dietary energy balance modulation of Kras- and Ink4a/Arf+/--driven pancreatic cancer: the role of insulin-like growth factor-I.

Cancer prevention research (Philadelphia, Pa.) - 1 Oct 2013

Lashinger Laura M, Harrison Lauren M, Rasmussen Audrey J, Logsdon Craig D, Fischer Susan M, McArthur Mark J, Hursting Stephen D

Abstract excerpt

New molecular targets and intervention strategies for breaking the obesity-pancreatic cancer link are urgently needed. Using relevant spontaneous and orthotopically transplanted murine models of pancreatic cancer, we tested the hypothesis that dietary energy balance modulation impacts pancreatic cancer development and progression through an insulin-like growth factor (IGF)-I-dependent mechanism. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Body Composition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caloric Restriction

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Disease-Free Survival

Share to Energy Metabolism

Share to Insulin-Like Growth Factor I

Share to Neoplasm Transplantation

Source

Open in PubMed Open full text

Identifiers

PMID: 23980075
DOI: 10.1158/1940-6207.CAPR-13-0185
PMCID: PMC3874288

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dietary energy balance modulation of Kras- and Ink4a/Arf+/--driven pancreatic cancer: the role of insulin-like growth factor-I.PMID 23980075Read ↗

High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model.Semantic proximity Read ↗

Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice.Semantic proximity Read ↗

Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma.Semantic proximity Read ↗

Endogenous insulin contributes to pancreatic cancer developmentSemantic proximity Read ↗

Dietary protein governs the role of insulin signaling in the postprandial regulation of hepatic mTORC1Semantic proximity Read ↗

Physical Activity Delays Obesity-Associated Pancreatic Ductal Adenocarcinoma in Mice and Decreases InflammationSemantic proximity Read ↗

KRAS: feeding pancreatic cancer proliferation.Semantic proximity Read ↗

Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumorsSemantic proximity Read ↗

Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.Semantic proximity Read ↗

KRAS, YAP, and obesity in pancreatic cancer: A signaling network with multiple loops.Semantic proximity Read ↗

Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.