Article

Comparative and Integrative Single Cell Analysis Reveals New Insights into the Transcriptional Immaturity of Stem Cell-Derived β Cells

2023-11-17

Abstract excerpt

<h4>Summary</h4> Diabetes cell replacement therapy has the potential to be transformed by human pluripotent stem cell-derived β cells (SC-β cells). However, the precise identity of SC-β cells in relationship to primary fetal and adult β-cells remains unclear. Here, we used single-cell sequencing datasets to characterize the transcriptional identity of islets from in vitro differentiation, fetal islets, and adult...

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Literature Corpus work: dd89e2da-37aa-589f-bb0d-284a164481ae
DOI: 10.1101/2023.11.15.567281

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