Article

Senataxin modulates resistance to cisplatin through an R-loop mediated mechanism in HPV-associated Head and Neck Squamous Cell Carcinoma

2024-02-22

Abstract excerpt

<h4>Introduction</h4> Oropharyngeal Squamous Cell Carcinoma (OPSCC) is a site defined subtype of head and neck cancer with two distinct clinical subtypes: HPV-associated (HPV+) and HPV-independent (HPV-); both of which are commonly treated with chemoradiotherapy involving cisplatin. Cisplatin creates DNA crosslinks, which lead to eventual cell death via apoptosis. Clinical outcomes in HPV-OPSCC are poor and altho...

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Literature Corpus work: 8fc9190a-40d8-5b0d-9151-ea1d3cb7afef
DOI: 10.1101/2024.02.22.581374

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