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Targeting DNA damage response as a potential therapeutic strategy for head and neck squamous cell carcinoma

21 Oct 2022

Abstract excerpt

Cells experience both endogenous and exogenous DNA damage daily. To maintain genome integrity and suppress tumorigenesis, individuals have evolutionarily acquired a series of repair functions, termed DNA damage response (DDR), to repair DNA damage and ensure the accurate transmission of genetic information. Defects in DNA damage repair pathways may lead to various diseases, including tumors. Accumulating evidence...

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PMID: 36338767
DOI: 10.3389/fonc.2022.1031944

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