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Frequent mutations in TP53 and CDKN2A found by next-generation sequencing of head and neck cancer cell lines.

Archives of otolaryngology--head & neck surgery - 1 Aug 2012

Nichols Anthony C, Yoo John, Palma David A, Fung Kevin, Franklin Jason H, Koropatnick James, Mymryk Joe S, Batada Nizar N, Barrett John W

Abstract excerpt

OBJECTIVE: To conduct high-throughput mutational analysis in 6 commonly used head and neck cancer cell lines. Comprehensive mutation analysis of primary head and neck squamous cell carcinoma (HNSCC) tumors has recently been reported, and mutations in the NOTCH receptors, TP53 and CDKN2A, were key findings. Established cell lines are valuable tools to study cancer in vitro. Similar high-throughput mutational...

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PMID: 22911296
DOI: 10.1001/archoto.2012.1558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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