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DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors

28 Feb 2022

Abstract excerpt

BACKGROUND: Pancreatic neuroendocrine neoplasms (PanNENs) fall into two subclasses: the well-differentiated, low- to high-grade pancreatic neuroendocrine tumors (PanNETs), and the poorly-differentiated, high-grade pancreatic neuroendocrine carcinomas (PanNECs). While recent studies suggest an endocrine descent of PanNETs, the origin of PanNECs remains unknown. METHODS: We performed DNA methylation analysis for 57...

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Lung Cancer Research Studies
Neuroendocrine Tumor Research Advances
Pancreatic and Hepatic Oncology Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35227293
DOI: 10.1186/s13073-022-01018-w

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