Article
Molecular Subtypes of Pancreatic Neuroendocrine Tumors Mutated in MEN1/DAXX/ATRX Explain Biological Variability.
Endocrine pathology - 10 Nov 2025
Avanthay Simona, Di Domenico Annunziata, Kirchner Philipp, Bräutigam Konstantin, Chouchane Aziz, Maire Renaud, Thirlwell Christina, Kim-Fuchs Corina, Perren Aurel, Marinoni Ilaria
Abstract excerpt
About 40% of non-functioning (NF) Pancreatic Neuroendocrine Tumors (PanNETs) harbour mutations in MEN1, often co-occurring with DAXX/ATRX. While the ADM group (MEN1 and DAXX/ATRX co-mutated) exhibits homogeneous genetic and epigenetic features and a consistent risk of relapse, it shows considerable variability in treatment response, suggesting an underlying molecular diversity. In this study we aimed to elucidate...
Read the complete abstract on PubMedTopics
- Humans
- Pancreatic Neoplasms
- Neuroendocrine Tumors
- Co-Repressor Proteins
- Mutation
- X-linked Nuclear Protein