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Article

<i>ATRX, DAXX or MEN1</i> mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup

2017-09-28

Abstract excerpt

The most commonly mutated genes in pancreatic neuroendocrine tumors (PanNETs) are ATRX , DAXX , and MEN1 . Little is known about the cells-of-origin for non-functional neuroendocrine tumors. Here, we genotyped 64 PanNETs for mutations in ATRX , DAXX , and MEN1 and found 37 tumors (58%) carry mutations in these three genes (A-D-M mutant PanNETs) and this correlates with a worse clinical outcome than tumors ca...

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Identifiers and source

Literature Corpus work
d942bd74-7f7d-5488-b220-644197fec1b6
DOI
10.1101/195214
Open publication

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<i>ATRX, DAXX or MEN1</i> mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroupDOI 10.1101/195214
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