An Overview of Stress Response and Hypometabolic Strategies in <i>Caenorhabditis elegans</i>: Conserved and Contrasting Signals with the Mammalian System

Abstract excerpt

Studies of the molecular mechanisms that are involved in stress responses (environmental or physiological) have long been used to make links to disease states in humans. The nematode model organism, Caenorhabditis elegans, undergoes a state of hypometabolism called the 'dauer' stage. This period of developmental arrest is characterized by a significant reduction in metabolic rate, triggered by ambient temperature...

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