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p300 inhibition delays premature cellular senescence

10 Jul 2025

Abstract excerpt

Cellular senescence represents a permanent state of cell cycle arrest, also observed in neurodegenerative disorders. As p300 has been identified as an epigenetic driver of replicative senescence, we aimed to investigate whether in vitro p300 inhibition could rescue the stress-induced premature senescence (SIPS) phenotype. We exploited 2D and 3D (brain organoids) in vitro models of SIPS using two different...

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PMID: 40640194
DOI: 10.1038/s41514-025-00251-y

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