Article

Genetic manipulation using hepatocyte-targeting adeno-associated viral vectors has minimal off-target effects

2021-02-19

Abstract excerpt

Mice are a widely used pre-clinical model system in large part due to their potential for genetic manipulation. The ability to manipulate gene expression in specific cells under temporal control is a powerful experimental tool. The liver is central to metabolic homeostasis and a site of many diseases, making the targeting of hepatocytes attractive. Adeno-Associated Virus 8 (AAV8) vectors are valuable instruments f...

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Literature Corpus work: 7c26b52f-76df-50ca-a77d-f6c457d625f0
DOI: 10.1101/2021.02.19.431990

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