Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs

1 May 2009

Abstract excerpt

BACKGROUND: The presence of multiple copies of porcine endogenous retrovirus (PERV) within the pig genome, and the demonstration that replication competent PERV, that infect human cells in culture, can be isolated from pig cells, directly impacts the drive towards the development of pigs for xenotransplantation. The development of technology to produce pigs that do not propagate PERV has the potential to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Genetics and Reproduction
Share to Virus-based gene therapy research
Share to Xenotransplantation and immune response

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19566656
DOI: 10.1111/j.1399-3089.2009.00525.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAsPMID 19566656Read ↗

Knockdown of porcine endogenous retrovirus (PERV) expression by PERV‐specific shRNA in transgenic pigsSemantic proximity Read ↗

Long‐term effects of PERV‐specific RNA interference in transgenic pigsSemantic proximity Read ↗

Prevention of PERV Infections in Pig to Human Xenotransplantation by the RNA Interference Silences GeneSemantic proximity Read ↗

How Active Are Porcine Endogenous Retroviruses (PERVs)?Semantic proximity Read ↗

Elimination of porcine endogenous retroviruses from pig cellsSemantic proximity Read ↗

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9Semantic proximity Read ↗

Distribution and expression of porcine endogenous retroviruses in multi‐transgenic pigs generated for xenotransplantationSemantic proximity Read ↗

Mice Transgenic for a Human Porcine Endogenous Retrovirus Receptor Are Susceptible to Productive Viral InfectionSemantic proximity Read ↗

Pig endogenous retroviruses and xenotransplantationSemantic proximity Read ↗

Infection Barriers to Successful Xenotransplantation Focusing on Porcine Endogenous RetrovirusesSemantic proximity Read ↗

Targeted Integration of siRNA against Porcine Cytomegalovirus (PCMV) Enhances the Resistance of Porcine Cells to PCMVSemantic proximity Read ↗

Chapter 5: Strategies to prevent transmission of porcine endogenous retrovirusesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.