Article

Biology-inspired data-driven quality control for scientific discovery in single-cell transcriptomics

2021-10-28

Abstract excerpt

Quality control (QC) of cells, a critical step in single-cell RNA sequencing data analysis, has largely relied on arbitrarily fixed data-agnostic thresholds on QC metrics such as gene complexity and fraction of reads mapping to mitochondrial genes. The few existing data-driven approaches perform QC at the level of samples or studies without accounting for biological variation in the commonly used QC criteria. We d...

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Literature Corpus work: 01f6505b-311f-5b76-8607-ba0acd7e18d1
DOI: 10.1101/2021.10.27.466176

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