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Article

The interferon landscape along the respiratory tract impacts the severity of COVID-19

19 Aug 2021

Abstract excerpt

Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) families remains debated. We scrutinized the production of IFNs along the respiratory tract of COVID-19 patients and found that high levels of IFN-III, and to a lesser extent IFN-I, characterize the upper airways of patients with high...

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PMID: 34492226
DOI: 10.1016/j.cell.2021.08.016

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