Article

Histone H4 lysine 20 monomethylation is not a mark of transcriptional silencers

2025-01-13

Abstract excerpt

Transcriptional silencers are cis -regulatory elements that downregulate the expression of target genes. Although thousands of silencers have been identified experimentally, a predictive chromatin signature of silencers has not been found. H4K20me1 previously was reported to be highly enriched among human silencers, but our reanalysis of the data using an appropriate background revealed that the enrichment is onl...

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Literature Corpus work: dd2f0291-924d-55a4-8569-a52c5e0efc5c
DOI: 10.1101/2025.01.09.632211

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