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Article

Cellular Cytotoxicity of Next-Generation CD20 Monoclonal Antibodies

8 Aug 2018

Abstract excerpt

Abstract CD20 monoclonal antibodies (CD20 mAb) induce cellular cytotoxicity, which is traditionally measured by antibody-dependent cellular cytotoxicity (ADCC) assays. However, data suggest that antibody-dependent cellular phagocytosis (ADCP) is the primary cytotoxic mechanism. We directly compared in vitro ADCP versus ADCC using primary human cells. After establishing the primacy of ADCP, we examined...

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PMID: 30089638
DOI: 10.1158/2326-6066.cir-18-0319

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