Article

<i>FBXO42</i> activity is required to prevent mitotic arrest, spindle assembly checkpoint activation, and lethality in glioblastoma and other cancers

2022-12-01

Abstract excerpt

Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. To identify genes differentially required for the viability of GBM stem-like cells (GSCs), we performed functional genomic lethality screens comparing GSCs and control human neural stem cells. Among top scoring hits in a subset of GBM cells was the F-box-containing gene FBXO42 , which was also essential in ∼15% of cell lines derived from...

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Literature Corpus work: dd1ba0b7-831b-5094-8cab-d052c4b67d38
DOI: 10.1101/2022.11.29.518420

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