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Article

Sensitivity to BUB1B Inhibition Defines an Alternative Classification of Glioblastoma

30 Aug 2017

Abstract excerpt

Abstract Glioblastoma multiforme (GBM) remains a mainly incurable disease in desperate need of more effective treatments. In this study, we develop evidence that the mitotic spindle checkpoint molecule BUB1B may offer a predictive marker for aggressiveness and effective drug response. A subset of GBM tumor isolates requires BUB1B to suppress lethal kinetochore–microtubule attachment defects. Using gene expression...

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PMID: 28855212
DOI: 10.1158/0008-5472.can-17-0736

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