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Parallel evolution of phage resistance - virulence trade - offs during <i>in vitro</i> and nasal <i>Pseudomonas aeruginosa</i> phage treatment

2021-09-06

Abstract excerpt

With rising antibiotic resistance, there has been increasing interest in treating pathogenic bacteria with bacteriophages (phage therapy). One limitation of phage therapy is the ease at which bacteria can evolve resistance. Negative effects of resistance may be mitigated when resistance results in reduced bacterial growth and virulence, or when phage coevolve to overcome resistance. Resistance evolution and its co...

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Literature Corpus work
8a78d980-abaf-566d-b881-d1c9004bf06a
DOI
10.1101/2021.09.06.459069
Open publication

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Parallel evolution of phage resistance - virulence trade - offs during <i>in vitro</i> and nasal <i>Pseudomonas aeruginosa</i> phage treatmentDOI 10.1101/2021.09.06.459069
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