Article

Modelling the synergistic effect of bacteriophage and antibiotics on bacteria: killers and drivers of resistance evolution

2022-03-02

Abstract excerpt

<h4>ABSTRACT</h4> Bacteriophage (phage) are bacterial predators that can also spread antimicrobial resistance (AMR) genes between bacteria by generalised transduction. Phage are often present alongside antibiotics in the environment, yet evidence of their joint killing effect on bacteria is conflicted, and the dynamics of transduction in such systems are unknown. Here, we combine in vitro data and mathematical m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9bc9ab29-113f-58e5-8d41-a0106481fa4e
DOI: 10.1101/2022.03.02.480504

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modelling the synergistic effect of bacteriophage and antibiotics on bacteria: killers and drivers of resistance evolutionDOI 10.1101/2022.03.02.480504Read

Unraveling Resistance and Thresholds in Phage Therapy Using <i>Staphylococcus aureus</i> In Vitro ModelsSemantic proximity Read

Joint antibiotic and phage therapy: addressing the limitations of a seemingly ideal phage for treating <i>Staphylococcus aureus</i> infectionsSemantic proximity Read

Phage therapy: A targeted approach to overcoming antibiotic resistanceSemantic proximity Read

Modelling phage-bacteria interactions driving predation and horizontal gene transferSemantic proximity Read

Phage-Antibiotic Combination Treatments: Antagonistic Impacts of Antibiotics on the Pharmacodynamics of Phage Therapy?Semantic proximity Read

Phage-Antibiotic Synergy Is Driven by a Unique Combination of Antibacterial Mechanism of Action and StoichiometrySemantic proximity Read

Bacteriophage Therapeutics: A Primer for Clinicians on Phage‐Antibiotic CombinationsSemantic proximity Read

Phage Therapy: Combating Evolution of Bacterial Resistance to PhagesSemantic proximity Read

Building reusable phage and antibiotic treatments via exploitation of bacteria-phage coevolutionary dynamicsSemantic proximity Read

Modeling multiphage-bacteria kinetics to predict phage therapy potency and longevitySemantic proximity Read

Bacteriophages: A Therapy Concept against Multi-Drug–Resistant BacteriaSemantic proximity Read

Fitness Trade-Offs Resulting from Bacteriophage Resistance Potentiate Synergistic Antibacterial Strategies.Semantic proximity Read