Article
Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P4-ATPase ATP8A2.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2012
Coleman Jonathan A, Vestergaard Anna L, Molday Robert S, Vilsen Bente, Andersen Jens Peter
Abstract excerpt
ATP8A2 is a P(4)-ATPase ("flippase") located in membranes of retinal photoreceptors, brain cells, and testis, where it mediates transport of aminophospholipids toward the cytoplasmic leaflet. It has long been an enigma whether the mechanism of P(4)-ATPases resembles that of the well-characterized cation-transporting P-type ATPases, and it is unknown whether the flippases interact directly with the lipid and with...
Topics
- Adenosine Triphosphatases
- Animals
- Biological Transport
- Electrophoresis, Polyacrylamide Gel
- Lysine
- Mutation
- Phospholipids
- Phosphorylation
- Photoreceptor Cells, Vertebrate
- Vanadates