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Article

Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs

10 Aug 2023

Abstract excerpt

Background: Smoking-associated DNA methylation levels identified through epigenome-wide association studies (EWASs) are generally ascribed to smoking-reactive mechanisms, but the contribution of a shared genetic predisposition to smoking and DNA methylation levels is typically not accounted for. Methods: We exploited a strong within-family design, that is, the discordant monozygotic twin design, to study...

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Share to Epigenetics and DNA Methylation
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Share to Smoking Behavior and Cessation

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PMID: 37643467
DOI: 10.7554/elife.83286

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