Article

Development and validation of sensitive BCR::ABL1 fusion gene quantitation using next-generation sequencing

2022-12-05

Abstract excerpt

<h4>Background: </h4> BCR::ABL1 fusion has significant prognostic value and is screened for chronic myeloid leukaemia (CML) disease monitoring as a part of routine molecular testing. To overcome the limitations of the current standard real-time quantitative polymerase chain reaction (RQ-PCR), we designed and validated a next-generation sequencing (NGS)-based assay to quantify BCR::ABL1 and ABL1 transcript copy num...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dce28c3a-fb90-5635-90d3-48a491b1aa4a
DOI: 10.21203/rs.3.rs-2328608/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development and validation of sensitive BCR::ABL1 fusion gene quantitation using next-generation sequencingDOI 10.21203/rs.3.rs-2328608/v1Read

A Novel Next-Generation Sequencing Assay for the Identification of BCR::ABL1 Transcript Type and Accurate and Sensitive Detection of TKI-Resistant Mutations.Semantic proximity Read

A novel BCR-ABL1 fusion gene identified by next-generation sequencing in chronic myeloid leukemiaSemantic proximity Read

Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA.Semantic proximity Read

Next-Generation Digital Polymerase Chain Reaction Assay for BCR::ABL1 in Chronic Myeloid Leukemia: Comprehensive Validation Enabling Standardized Measurable Residual Disease DetectionSemantic proximity Read

A Highly Sensitive RNA-Based Mutation Detection Approach: Improve the Accuracy and Speed of Liquid Biopsy for Chronic Myeloid LeukemiaSemantic proximity Read

Digital PCR for BCR‐ABL1 Quantification in CML: Current Applications in Clinical PracticeSemantic proximity Read

Fusion Gene Detection and Quantification by Asymmetric Capture Sequencing (aCAP-Seq).Semantic proximity Read

Detection of Kinase Domain Mutations in BCR-ABL1 Leukemia by Ultra-deep Sequencing of Genomic DNASemantic proximity Read

Next-generation sequencing from chronic myeloid leukemia dried blood spots: insights and implications for global oncology.Semantic proximity Read

Next-generation sequencing for BCR-ABL1 kinase domain mutation testing in patients with chronic myeloid leukemia: a position paper.Semantic proximity Read

[Clinical Value of Detecting ABL Kinase Domain Mutations in Patients with Chronic Myeloid Leukemia Based on High-Throughput Sequencing Technology].Semantic proximity Read

Molecular monitoring of chronic myeloid leukemia: present and future.Semantic proximity Read