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Article

Next-generation sequencing from chronic myeloid leukemia dried blood spots: insights and implications for global oncology.

Leukemia - 1 Mar 2026

Oehler Vivian G, Sala-Torra Olga, Gilderman Neta, Beppu Lan, Woolston David W, Namaganda Priscilla, Rynning Jennifer, González Inés García, Towlerton Andrea, Voutsinas Jenna, Wu Qian, Yeung Cecilia C S, Radich Jerald P

Abstract excerpt

The goal of the "Spot On CML" program is to provide diagnostic and monitoring tests to chronic myeloid leukemia (CML) patients in low- and middle-income countries (LMICs). Previously, we demonstrated reproducible BCR::ABL1 transcript quantification using dried blood spots (DBS). We have now optimized methods of DNA and RNA extraction from DBS, allowing the detection of myeloid gene variants, including ABL1...

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Share to Fusion Proteins, bcr-abl
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Source

Identifiers

PMID: 41577999
DOI: 10.1038/s41375-025-02852-8

Genes

ABL1
ASXL1
BCR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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