Article
Fusion Gene Detection and Quantification by Asymmetric Capture Sequencing (aCAP-Seq).
The Journal of molecular diagnostics : JMD - 1 Nov 2022
Gricourt Guillaume, Tran Quang Violaine, Cayuela Jean-Michel, Boudali Elisa, Tarfi Sihem, Barathon Quentin, Daveau Romain, Joy Corine, Wagner-Ballon Orianne, Bories Dominique, Pautas Cécile, Maury Sébastien, Rea Delphine, Roy Lydia, Sloma Ivan
Abstract excerpt
Several fusion genes such as BCR::ABL1, FIP1L1::PDGFRA, and PML::RARA are now efficiently targeted by specific therapies in patients with leukemia. Although these therapies have significantly improved patient outcomes, leukemia relapse and progression remain clinical concerns. Most myeloid next-generation sequencing (NGS) panels do not detect or quantify these fusions. It therefore remains difficult to decipher...
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