Article
Common Kibra alleles are associated with human memory performance.
Science (New York, N.Y.) - 20 Oct 2006
Papassotiropoulos Andreas, Stephan Dietrich A, Huentelman Matthew J, Hoerndli Frederic J, Craig David W, Pearson John V, Huynh Kim-Dung, Brunner Fabienne, Corneveaux Jason, Osborne David, Wollmer M Axel, Aerni Amanda, Coluccia Daniel, Hänggi Jürgen, Mondadori Christian R A, Buchmann Andreas, Reiman Eric M, Caselli Richard J, Henke Katharina, de Quervain Dominique J-F
Abstract excerpt
Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic...
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