Article

Preferred left-handed conformations of glycyls with pathogenic variants protect against aggregation

2024-02-10

Abstract excerpt

Due to the lack of C β atom, the glycyl residues can exhibit left-handed Ramachandran conformations that are mostly disallowed for L-amino acids. The structural and functional significance of distinct glycyl conformations remains under-appreciated. Through systematic analyses of various datasets, we show that: i) the left-handed glycyl residues are over-represented at disease-associated sites and are evolutionari...

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Literature Corpus work: dcca8b93-3e99-5267-ab16-2736a15fff98
DOI: 10.1101/2024.02.09.579738

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