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Article

Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jun 2007

Xie Wei, Nangle Leslie A, Zhang Wei, Schimmel Paul, Yang Xiang-Lei

Abstract excerpt

Functional expansion of specific tRNA synthetases in higher organisms is well documented. These additional functions may explain why dominant mutations in glycyl-tRNA synthetase (GlyRS) and tyrosyl-tRNA synthetase cause Charcot-Marie-Tooth (CMT) disease, the most common heritable disease of the p...

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Source

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Identifiers

PMID: 17545306
DOI: 10.1073/pnas.0703908104
PMCID: PMC1891255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17545306-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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