Article

Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration

2021-03-22

Abstract excerpt

Growing evidence indicate that gut microbiota play a critical role in regulating the progression of neurodegenerative diseases, such as Parkinson’s disease (PD). The molecular mechanism underlying such microbe-host interaction is unclear. In this study, by feeding C. elegans expressing human α-syn with E. coli knockout mutants, we conducted a genome-wide screen to identify bacterial genes that promote host neuro...

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Literature Corpus work: dcb51321-f62b-542f-bf41-aebf54d48b9a
DOI: 10.1101/2021.03.22.436366

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