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Gut microbiota produces biofilm-associated amyloids with potential for neurodegeneration

16 May 2024

Abstract excerpt

Age-related neurodegenerative diseases involving amyloid aggregation remain one of the biggest challenges of modern medicine. Alterations in the gastrointestinal microbiome play an active role in the aetiology of neurological disorders. Here, we dissect the amyloidogenic properties of biofilm-associated proteins (BAPs) of the gut microbiota and their implications for synucleinopathies. We demonstrate that BAPs...

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PMID: 38755164
DOI: 10.1038/s41467-024-48309-x

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