Article

Dietary fibre deprivation and bacterial curli exposure shift gut microbiome and exacerbate Parkinson's disease-like pathologies in an alpha-synuclein-overexpressing mouse

2022-03-22

Abstract excerpt

The microbiome-gut-brain axis has been proposed as a pathogenic path in Parkinson's disease (PD). Dietary driven dysbiosis and reduced gut barrier function could facilitate the interaction of toxic external or internal factors with the enteric nervous system, where PD could start. Amyloid bacterial protein such as curli can act as seed to corrupt enteric alpha-synuclein and lead to its aggregation. Misfolded alpha...

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Literature Corpus work: 727c0935-e4e3-57fe-975c-8d06a9308fab
DOI: 10.1101/2022.03.21.485143

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